Exposures in Pregnancy:
In-Utero Exposure to Drugs - Monitoring and biological markers
Further Reading
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Hum Exp Toxicol. 1999 Apr;18(4):279-8
Klein J, Koren G: Hair analysis--a biological marker for passive smoking in pregnancy and childhood.
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Forens Sci Intl 70: 77-82, 1995.
Koren G: Measurement of drugs in neonatal hair: A window to fetal exposure.
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[Review][15 refs] [Hebrew] Harefuah. 129(9):336-8, 1995 Nov 1. No Abstract available.
Ben David S. Measurement of drugs in neonatal hair--a window to fetal exposure]
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N Engl J Med 328: 66-67, 1993.
Klein J, Chitayat D, Koren G: Hair as a biological marker for intrauterine exposure to cigarette smoking
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Koren G, Klein J, Forman R, Graham K, My-Khan P: Biological Markers of intrauterine exposure to cocaine and cigarette smoking. Dev Pharmacol Ther 18: 228-236, 1992.
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JAMA 271(8):621-3, 1994.
Eliopoulos C, Klein J, Phan MK, Knie B, Greenwald M, Chitayat D, Koren G: Hair concentrations of nicotine and cotinine in women and newborn infants.
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J Clin Pharmacol 32: 671-675, 1992.
Koren G, Klein J, Forman R, Graham K: Hair Analysis of cocaine: Differentiation between systemic exposure and external contamination.
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Koren G, Klein J, Graham K, Forman R: Hair test to varify gestational cocaine exposure. In: Recent Developments in TDM and Clin Toxicology Marcel Dekker, NY 569-574, 1992.
In Book:
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Graham K, Klein J, Forman R, Flynnk, Sakuma T, Davidson W, Koren G: Potential misclassification of a case of SIDS: Maternal and neonatal hair analysis for cocaine and heroin. Maternal Fetal Med 2: 91-93, 1993.
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Johnson D, Schwartz H, Forman R, Klein J, Jacobson, S, Greenwald M, Koren G: Assessment of in utero exposure to cocaine; Radioimmunoassay testing for benzoylecgonine in meconium, neonatal hair and maternal hair. Can J Clin Pharmacol 1: 83-86, 1994.
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JAMA 262: 3328-3330, 1989.
Graham K, Koren g, Klein J, Schneiderman J: Determination of gestational cocaine exposure by hair analysis.
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Eliopoulos C, Klein J, Koren G: Neonatal markers for intrauterine exposure to cocaine and nicotine. Can J Obstet Gynecol 6: 615-620, 1994.
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Life Sci 50: 1333-1341, 1992.
Forman R, Graham K, Klein J, Greenwald M, Koren G: Accumulation of cocaine in fetal hair; The dose response curve.
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Koren G: TDM in Pregnacy. In: Recent developments in TDM and Clinical Toxicology, Marcel Dekker, NY, pp 53-62, 1992.
In Book:
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Drug Intell Clin Pharm 22: 813-824, 1988.
Einarson TR, Leeder JS, Koren G: A Method for meta analysis of epidemiological studies.
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Klein J, Koren G: Neonatal hair analysis-a tool for the assessment of in utero exposure to drugs. NIDA (In Press).
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Koren G, Ben David S: Drug and Chemical monitoring using neonatal hair. Is Med Assoc J 129:336-338, 1995.
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J Toxicol Clin Toxicol 2001; 39: 361-6.
Ursitti F, Klein J, Sellers E, Koren G: Use of hair analysis for confirmation of self-reported cocaine use in users with negative urine tests.
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Neonatal hair test for cocaine:Toronto experience
Gideon Koren, MD FRCPC; Julia Klein, MSC